Upcoming Events

  1. MSTP Winter Quarter Journal Club

    January 8, 2015 @ 5:45 pm - 7:00 pm
  2. MSTP Dinner Meeting

    January 15, 2015 @ 6:00 pm - 8:00 pm
  3. MSTP Winter Quarter Journal Club

    January 22, 2015 @ 5:45 pm - 7:00 pm

What’s Happening

UW MSTP students sequenced the whole genome of a cadaver during their first year medical school human anatomy course. The patient had died from complications of pulmonary fibrosis. The genome revealed a risk factor, in the form of a genetic variant involved in mucous production. The variant’s association with pulmonary fibrosis had been previously known, but this is the first time the whole genome of someone with this variant has been sequenced, thereby permitting assessment of its causative role. In this revolutionary educational and research exercise, students worked cooperatively in the gross anatomy lab, participated in gross and microscopic pathological examination of tissue, completed genome sequencing, performed sophisticated computational analysis of genomic data, and worked together to write the manuscript.

UW MSTP student Greg Findlay (E-12) is co-first author on a new Nature paper. The paper presents a new technique to create hundreds to thousands of targeted mutations in the human genome and assess the consequences of each one in a rapid and cost-effective manner. Greg is starting his 3rd year in the MSTP and is conducting his PhD work in the Shendure Lab.

UW MSTP student Andrew Stergachis (E-07) is co-first author on a featured Cell paper pointing to changes in regulatory DNA landscapes as quantitative indicators of cell-fate transitions, lineage relationships, and dysfunction. Andrew completed his PhD work in John Stamatoyannopoulos’ lab and recently returned to medical school to resume his clinical education.