Upcoming Events

  1. MSTP Dinner Meeting

    January 4, 2018 @ 6:00 pm - 9:00 pm
  2. MSTP Journal Club

    January 11, 2018 @ 5:45 pm - 7:00 pm
  3. MSTP Dinner Meeting

    January 18, 2018 @ 6:00 pm - 9:00 pm
  4. MSTP Journal Club

    January 25, 2018 @ 5:45 pm - 7:00 pm

What’s Happening

E-11 MSTP student Aaron Seo has a Blood publication describing bone marrow failure in 3 unrelated families caused by inherited mutations in the gene encoding thrombopoietin, an important growth factor for blood cell development produced primarily in the liver and kidney. The mutations result in a lack of thrombopoietin in patients’ serum. Though patients do not respond to transplant, treatment with a thrombopoietin mimetic was able to improve blood counts across all lineages.

UW MSTP student Jack Rose (E-10) has a new Nature Methods publication in collaboration with fellow E-11 MSTP student BJ Valente in which they developed two new tools: ciCas9—a rapidly inducible Cas9 construct, and DSB-ddPCR—a method for time-resolved quantification of double strand breaks in DNA. Using these tools, they investigated CRISPR/Cas9 editing kinetics in human cells.

E-12 UW MSTP student Chris Arakawa (Bioengineering, DeForest Lab) has a new Advanced Materials paper in which he showcases a new way to create blood vessels using lasers and a synthetic light sensitive biomaterial. Using this novel technique and material he successfully has created the world’s smallest artificial human blood vessels to date with complete 4D control and demonstrates a way to create devices and architectures inside the vessel lumen.

UW MSTP students Madeleine Geisheker (E-12, first author) and Gabe Heymann (E-13, second author) have a new Nature Neuro paper characterizing the properties of missense mutations in those with autism and other neurodevelopment disorders showing these mutations tend to cluster in specific regions important to protein function, and in genes involved in neuronal signaling.