Upcoming Events

  1. MSTP Autumn Quarter Journal Club

    December 3 @ 5:45 pm - 7:00 pm
  2. MSTP Autumn Quarter Journal Club

    December 10 @ 5:45 pm - 7:00 pm
  3. MSTP Winter Quarter Journal Club

    January 14, 2016 @ 5:45 pm - 7:00 pm
  4. MSTP Winter Quarter Journal Club

    January 28, 2016 @ 5:45 pm - 7:00 pm

What’s Happening

UW MSTP student Michael Zhang (E-08) is first author on a recent Nature Genetics paper the discovery of a new familial syndrome associated with low blood platelets and predisposition to diverse blood malignancies. The study has implications for the diagnosis and clinical management of patients with this disorder and also identifies an important role for the ETV6 gene in blood cell formation and malignant transformation. Michael completed his PhD work in the labs of Akiko Shimamura and Mary-Claire King. He is now his third-year of medical school.

UW MSTP students sequenced the whole genome of a cadaver during their first year medical school human anatomy course. The patient had died from complications of pulmonary fibrosis. The genome revealed a risk factor, in the form of a genetic variant involved in mucous production. The variant’s association with pulmonary fibrosis had been previously known, but this is the first time the whole genome of someone with this variant has been sequenced, thereby permitting assessment of its causative role. In this revolutionary educational and research exercise, students worked cooperatively in the gross anatomy lab, participated in gross and microscopic pathological examination of tissue, completed genome sequencing, performed sophisticated computational analysis of genomic data, and worked together to write the manuscript.

UW MSTP student Greg Findlay (E-12) is co-first author on a new Nature paper. The paper presents a new technique to create hundreds to thousands of targeted mutations in the human genome and assess the consequences of each one in a rapid and cost-effective manner. Greg is starting his 3rd year in the MSTP and is conducting his PhD work in the Shendure Lab.