Upcoming Events

  1. MSTP Journal Club

    April 9 @ 5:30 pm - 6:45 pm
  2. MSTP Journal Club

    April 16 @ 5:30 pm - 6:45 pm
  3. MSTP Journal Club

    April 30 @ 5:30 pm - 6:45 pm
  4. MSTP Journal Club

    May 7 @ 5:30 pm - 6:45 pm

What’s Happening

MSTP student (E-14) Sanjay Srivatsan’s research on massively multiplex chemical transcriptomics at single cell resolution has been published in December’s Science publication. This article explores the use of sci-Plex, which uses ‘nuclear hashing’ to quantify global transcriptional responses to thousands of independent perturbations at single-cell resolution. Their results reveal substantial intercellular heterogeneity in response to specific compounds, commonalities in response to families of compounds, and insight into differential properties within families.

E-13 student Nicole Naiman has two recent publications relating to her research on HIV. The first, published in August 2019, appears in the Journal of Infectious Diseases, and addresses mother-to-child HIV transmission. This publication reviews an association between plasma antibody binding to the gp41 ectodomain in breastfeeding mothers to increased odds of transmission to the infant. Her next publication appears in EBioMedicine September 2019 and reviews HIV-infected infant mortality. This article also addresses HIV transmission, but focuses on antibody-dependent cellular cytotoxicity in predicting infant mortality. In a cohort of high-risk mother-infant pairs, breast milk ADCC activity was correlated with reduced risk of MTCT.

E-13 MSTP student David Caldwell’s publication in Frontiers in Neuroscience looks into electrocorticographic brain computer interfaces, which offer opportunities to restore brain function in individuals suffering from neurological damage. This article reviews ECoG electrodes, the physics and physiology of DES, and the use of electrical stimulation of the brain for the clinical treatment of disorders such as epilepsy and Parkinson’s disease. It also explores enabling technologies, such as smaller ECoG electrodes for more precise targeting of cortical areas, signal processing strategies for simultaneous simulation and recording, and computational modeling and algorithms for tailoring simulation to each individual brain.

E-13 MSTP student Mark Ragheb latest publication in DNA Repair explores the role of Mfd in replication-transcription conflicts in bacteria. DNA replication and transcription, a remarkable undertaking, must occur in a timely and accurate fashion in all organisms. This publication explores the conflicts in this process. Conflicts can lead to various detrimental outcomes, including replication fork stalling, double-stranded DNA breaks (DSBs), and mutations. They discuss in detail how different states of RNAP can impact replisome progression, and largely focus on one highly conserved RNAP associated bacterial translocase, Mfd.

MSTP Student Alex Salter (E-12) has been named one of Forbes “30 Under 30″ in Healthcare. He is investigating how to enhance the efficacy of CAR T-cell therapy, a technique that utilizes synthetic proteins (CARs) to improve the ability of T cells to detect and destroy cancer cells, at Fred Hutchinson Cancer Research Center.